GAMMA GLOBULIN PRODUCTION IN GERMFREE RATS AFTER BACTERIAL CONTAMINATION
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چکیده
منابع مشابه
Gamma Globulin Production in Germfree Rats after Bacterial Contamination
The earlier observed pronounced hypogammaglobulinemia in germfree rats of different ages has been confirmed. Using an immunologic technique the concentration of immunologic gamma globulins were found to vary between 10 and 15 per cent of the values observed in ordinary rats. Upon contamination of germfree rats with the normal microbial flora a pronounced lag phase was noted before the gamma glo...
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A method for the isolation of rat 7S gamma globulin based on multiple adsorptions with DEAE-Sephadex A-50 has been presented. The separation of rat 7S globulin requires a procedure modified from the one used for humans in terms of the buffer pH, and the number of adsorptions. Ultracentrifugal analysis indicates the resulting fraction is a single component. In addition, immunoelectrophoresis of ...
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In a colony of germfree rats 50 per cent of the males had urinary calculi composed of calcium citrate and calcium oxalate. Genetically closely related conventional animals on the same sterilized diet did not present a single case of stone formation. The tendency to calculus formation disappeared when germfree animals were contaminated with the intestinal flora from conventional rats. The calcul...
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No urobilinogens are present in the feces or urine of germfree rats. After contamination of germfree animals with feces from conventional animals the exgermfree rats produced urobilins to the same extent as conventional animals on the same diet. The negative urobilin test turned positive in germfree animals infected with a single Clostridium-like microorganism isolated from the intestinal conte...
متن کاملHemorrhagic shock of germfree rats’
MCNULTY, Mr. P., JR. AND RAFAEL LINARES. Hemorrhagic shock ofgermfree rats. Am. J. Physiol. Ig8( I) : 141-144. 1g6o.Germfree and ordinarv laboratory rats of the same strain, half of each sort treated with oral aureomycin for 3 days prior to shock, were subjected to hemorrhagic shock. At the level and duration of hypotension selected, the procedure was highly lethal for all four groups. The sing...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1959
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.110.5.675